In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a family of natural products showing a wide range of structural diversity and biological and pharmaceutical activity, has been based either on continuation or improvement of known traditional methods or on new, recently developed, strategies. Both diastereoselective and enantioselective catalytic methods have been applied. This review describes the stereochemically modified traditional syntheses (the Pictet-Spengler, the Bischler-Napieralski, and the Pomeranz-Fritsch- Bobbitt) along with strategies based on closing of the nitrogen-containing ring B of the isoquinoline core by the formation of bonds between C-1-N-2, N-2-C-3, C-1-N-2/N-2-C-3, and C-1-N-2/C-4-C-4a atoms. Methods involving introduction of substituents at the Cl carbon of isoquinoline core along with syntheses applying various biocatalytic techniques have also been reviewed.