Bio-oil production from giant leucaena wood was performed by liquid-phase pyrolysis in the presence of decane as the solvent. Three different types of catalyst (ZSM-5, NiMo/Al2O3 and Pt/Al2O3) were evaluated in terms of the bio-oil production yield and quality in an autoclave reactor at a reaction temperature of 350A degrees C and initial hydrogen (H-2) pressure of 1 MPa with decane as the solvent. Although the yield was not significantly affected by the catalyst type, CHN analysis revealed that the NiMo/Al2O3 catalysts yielded bio-oil with the lowest oxygen content (10.0 wt. %) in 4.30 wt. % yield so that it was selected as the optimal catalyst. Optimization of the reaction temperature (at 250, 300, 350, and 400A degrees C) and the initial H-2 pressure (at 0.5, 1, 2, and 3 MPa) by sequential univariate analysis revealed that the reaction temperature had the greatest influence on the oil yield and oxygen content, reaching a yield of 8.60 wt. % with the lowest oxygen content of 8.50 % at 400A degrees C. Increasing the initial H-2 pressure diminished only slightly the oil and char yield and decreased the gas yield.