In previous studies, Patala-Nammal Composite Total Petroleum System (TPS) was recognized as a potential source of hydrocarbon in the Upper Indus Basin, and Sembar-Goru Composite TPS in the Lower Indus Basin. However, petroleum source-rock potential of Cretaceous strata in the Indus Basin is poorly known. In the current study, Rock Eval and total organic carbon (TOC) analyses were conducted to investigate the thermal maturity and source-rock potential of Cretaceous unit in the Lower Indus Basin. The Parh Formation of the Lower Indus Basin is lean in organic contents (TOC < 0.73%) and consistent with immature type-III/IV kerogen. The Upper Goru Formation is fair in organic contents and presents similar characteristics to the Parh Formation with respect to the hydrocarbon generation zone. The Lower Goru Formation presents fair to very good organic contents. The members of Lower Goru Formation have enough organic matter (OM) and are mature, with the exception of Badin shales. The OM, throughout the formation, is predominantly gas prone. The Sembar Formation is fair in organic contents and mature with respect to hydrocarbons generation. These results support that the Lower Goru rocks are comparatively more prospective with respect to hydrocarbons.