Dissipative particle dynamics with energy conservation (eDPD) is developed to simulate fluid-solid conjugate heat transfer in a microchannel. A temperature reset region placed ahead of a parallel-plate microchannel and a periodic boundary condition with a body force applied in the streamwise direction are used to generate the hydrodynamically developed, thermally developing flow. To insure the temperature and heat flux continuities at the fluid-solid interface, heat transfer in the fluid zone and solid zone is solved entirely, and an equivalent mesoscopic heat friction coefficient is proposed in the eDPD simulation. The results by eDPD method with the new numerical schemes agree well with those by the finite volume method (FVM) for the predictions of heat transfer in a thick-wall microchannel. (C) 2016 Elsevier Ltd. All rights reserved.