This study presents a computational parametric analysis of DME steam reforming in a large scale Circulating Fluidized Bed (CFB) reactor. The Computational Fluid Dynamic (CFD) model used, which is based on Eulerian-Eulerian dispersed flow, has been developed and validated in Part I of this study [1]. The effect of the reactor inlet configuration, gas residence time, inlet temperature and steam to DME ratio on the overall reactor performance and products have all been investigated. The results have shown that the use of double sided solid feeding system remarkable improvement in the flow uniformity, but with limited effect on the reactions and products. The temperature has been found to play a dominant role in increasing the DME conversion and the hydrogen yield. According to the parametric analysis, it is recommended to run the CFB reactor at around 300 degrees C inlet temperature, 5.5 steam to DME molar ratio, 4 s gas residence time and 37,104 ml g(cat)(-1)h(-1) space velocity. At these conditions, the DME conversion and hydrogen molar concentration in the product gas were both found to be around 80%. (C) 2016 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.