The thermophysical behavior of the binary mixtures N,N-dimethylacetamide + methanol and N,N-dimethylacetamide + ethanol has been studied through the measurement of density, rho, speed of sound, u, refractive index, n(D), and kinematic viscosity, v, over the entire mole fraction range at the temperatures of 283.15, 298.15 and 313.15 K and at p = 99.0 kPa. Excess volumes, V-E, excess isentropic compressibilities kappa(E)(S) refractive index deviations, Delta n(D), and viscosity deviations, Delta eta were also calculated and correlated with the Redlich-Kister equation. Both systems present negative excess volumes and excess isentropic compressibilities and positive refractive index deviations in the whole composition range. The viscosity deviations are positive for N,N-dirnethylacetamide + methanol and turn to negative for N,N-dimethylacetamide + ethanol. Moreover, both systems behave differently when temperature is raised. The experimental results were interpreted based on strength of specific interactions, size, and shape of molecules.