The infrared specta of hexamethylenetetramine (HMT) isolated in an argon matrix at 12 K, frozen in H2O at temperatures from 12 to 200 K, and as a pure solid, are reported. The results of ultraviolet photolysis of matrix-isolated HMT and HMT frozen in H2O ice are also presented, and implications for infrared astronomy and astrochemistry are discussed. Furthermore, a simple technique for incorporating large nonvolatile organic molecules into a matrix is described.