In this paper, we reported a VO2-based thermochromic window using bistratal glasses of TiO2 antireflection coating as well as Al: ZnO/SiO2 coatings, respectively. The thermochromic behavior of VO2 was modulated by TiO2 antireflection layers based on skin comfort design for the first time. The film thickness of TiO2(240 nm)/VO2(70 nm)/TiO2(10 nm)/Glass structure has been optimized based on modulation of 1350 similar to 2500 nm solar radiation by calculation. A remarkable improvement in mid-infrared reflectivity was obtained using Al: ZnO with SiO2 layer, and the film thickness has been optimized as SiO2 (similar to 100 nm)/Al: ZnO (300 nm)/Glass to achieve a suitable integrated luminous transmittance. This two multilayered stacks were combined together with different orders to form a multifunctional window for energy efficient fenestration. This work provides a new insight for structural design of multilayer thin films and serves as starting points for developing novel coatings for windows with superior energy efficiency.