Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physicochemical characterization, and in vitro skin permeation studies

Geun Young Noh; Ji Young Suh; Soo Nam Park

Korean Journal of Chemical Engineering, Vol.34, No.2, 400-406, February, 2017

DOI10.1007/s11814-016-0267-3 Export Citation

Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physicochemical characterization, and in vitro skin permeation studies

Geun Young Noh, Ji Young Suh, and Soo Nam Park^†

Cosmetic R&D Center, Department of Fine Chemistry, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea

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An optimized, ceramide-based, nanostructured lipid carrier (NLC) formulation was developed for isoliquiritigenin (ILTG), and its potential as a transdermal delivery system was evaluated. ILTG-loaded NLCs were prepared by blending solid (ceramide, cholesterol) and liquid lipids (caprylic/capric triglyceride) in various proportions using a hot homogenization and ultrasonication method. The physicochemical characteristics were investigated by DLS, ZP, EE%, TEM, DSC and XRD analyses and in vitro skin permeation studies. The results showed that the particle size of the formulation was 150.19-251.69 nm with a ZP>-20mV. The EE% was 56.45-89.97%. The NLC structure was influenced by lipid ratio, and increasing the caprylic/capric triglyceride ratio caused a less ordered structure, as confirmed by DSC. The XRD analysis indicated that ILTG was not in the crystalline state in all formulations. The skin permeation study showed that the ILTG-NLCs promoted ILTG permeation. In conclusion, ceramide-based NLCs could be a promising vehicle for the ILTG transdermal delivery of ILTG.

Keywords:Nanostructured Lipid Carrier;Transdermal Delivery System;Ceramide;Isoliquiritigenin;MEL

[References]

Wertz PW, Bergh B, Chem. Phys. Lipids, 91, 85 (1988)
Grayson S, Elias PM, J. Invest. Dermatol., 78, 128 (1982)
Nardo AD, Wertz P, Giannetti A, Seidenari S, Acta. Derm. Venereol. Suppl, 78, 27 (1998)
Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R, Arch. Dermatol. Res., 130, 452 (1994)
Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT, J. Invest. Dermatol., 90, 350 (1988)
Abraham W, Downing DT, Pharm. Res., 9, 1415 (1992)
Park SN, Lee MH, Kim SJ, Yu ER, Biochem. Biophys. Res. Commun., 435(3), 361 (2013)
Kim DH, Park WR, Kim JH, Cho EC, An EJ, Kim JW, Oh SG, Colloids Surf. B: Biointerfaces, 94, 236 (2012)
Wu X, Guy RH, J. Drug. Deliv. Sci. Technol., 19, 371 (2009)
Neupane YR, Srivastava M, Ahmad N, Kumar N, Bhatnagar A, Int. J. Pharm., 477, 601 (2014)
Choi WS, Cho HI, Lee HY, Lee SH, Choi YW, J. Pharm. Invest., 40, 373 (2010)
Pardeike J, Hommoss A, Muller RH, Int. J. Pharm., 366, 170 (2009)
Muller RH, Radtke M, Wissing SA, Int. J. Pharm., 242, 121 (2002)
Beloqui A, Solinis MA, Rodriguez-Gascon A, Almeida AJ, Preat V, Nanomedicine, 12, 143 (2016)
Zhao X, Mei W, Gong M, Zuo W, Bai H, Dai H, Molecules, 169, 775 (2011)
Zhang X, Yeung ED, Wang J, Panzhinskiy EE, Tong C, Li W, Li J, Clin. Exp. Pharmacol. Physiol., 37, 841 (2010)
Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S, J. Agric. Food Chem., 51, 1201 (2003)
Kim SC, Byun SH, Yang CH, Kim CY, Kim JW, Kim SG, Toxicology, 197, 239 (2004)
Zhang XY, Qiao H, Ni JM, Shi YB, Qiang Y, Eur. J. Pharm. Sci., 49, 411 (2013)
Kim SJ, Kwon SS, Jeon SH, Yu ER, Park SN, Int. J. Cosmet. Sci., 36, 553 (2014)
Jeon SH, Yoo CY, Park SN, Colloids Surf. B: Biointerfaces, 129, 7 (2015)
Kwon SS, Kim SY, Kong BJ, Kim KJ, Noh GY, Im NR, Lim JW, Ha JH, Kim J, Park SN, Int. J. Pharm., 483, 26 (2015)
Kwon SS, Kong BJ, Park SN, Eur. J. Pharm. Biopharm., 92, 146 (2015)
Jeong YM, Ha JH, Park SN, J. Ind. Eng. Chem., 35, 54 (2016)
Teeranachaideekul V, Boonme P, Souto EB, Muller RH, Junyaprasert VB, J. Control. Release, 128, 134 (2008)
Jores K, Mehnert W, Drechsler M, Bunjes H, Johann C, Mader K, J. Control. Release, 95, 217 (2004)
Fang JY, Fang CL, Liu CH, Su YH, Eur. J. Pharm. Biopharm., 70, 633 (2008)
Muller RH, Jacobs C, Kayser O, Adv. Drug Deliv. Rev., 47, 3 (2001)
Rodrigues LR, J. Colloid Interface Sci., 449, 304 (2015)
Ranpise NS, Korabu SS, Ghodake VN, Colloids Surf. B: Biointerfaces, 116, 81 (2014)
Kuo YC, Chen HH, Int. J. Pharm., 365, 206 (2009)
Gaur PK, Mishra S, Verma A, Verma N, J. Exp. Nanosci., 11, 38 (2016)
Shah R, Eldridge D, Palombo E, Harding I, SpringerInternational Publishing (2015).
Kovacevic A, Savic S, Vuleta G, Muller RH, Keck CM, Int. J. Pharm., 406, 163 (2011)
Han SB, Kwon SS, Jeong YM, Yu ER, Park SN, Int. J. Cosmet. Sci., 36, 588 (2014)
Li B, Liu B, Li J, Xiao H, Wang J, Liang G, Int. J. M. Sci., 16, 17999 (2015)
Neupane YR, Srivastava M, Ahmad N, Kumar N, Bhatnagar A, Kohli K, Int. J. Pharm., 477, 601 (2014)
Shamma RN, Aburahma MH, Int. J. Nanomedicine, 9, 5449 (2014)
Pradhan M, Singh D, Singh MR, Chem. Phys. Lipids, 186, 9 (2015)
Chen H, Wang Y, Zhai Y, Zhai G, Wang Z, Colloids Surf. A: Physicochem. Eng. Asp., 465, 130 (2015)
Souto EB, Wissing SA, Barbosa CM, Muller RH, Int. J. Pharm., 278, 71 (2004)
Zhai Y, Zhai G, J. Control. Release, 193, 90 (2014)

[Referenced By]

[1] Wertz PW, Bergh B, Chem. Phys. Lipids, 91, 85 (1988)

[2] Grayson S, Elias PM, J. Invest. Dermatol., 78, 128 (1982)

[3] Nardo AD, Wertz P, Giannetti A, Seidenari S, Acta. Derm. Venereol. Suppl, 78, 27 (1998)

[4] Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R, Arch. Dermatol. Res., 130, 452 (1994)

[5] Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT, J. Invest. Dermatol., 90, 350 (1988)

[6] Abraham W, Downing DT, Pharm. Res., 9, 1415 (1992)

[7] Park SN, Lee MH, Kim SJ, Yu ER, Biochem. Biophys. Res. Commun., 435(3), 361 (2013)

[8] Kim DH, Park WR, Kim JH, Cho EC, An EJ, Kim JW, Oh SG, Colloids Surf. B: Biointerfaces, 94, 236 (2012)

[9] Wu X, Guy RH, J. Drug. Deliv. Sci. Technol., 19, 371 (2009)

[10] Neupane YR, Srivastava M, Ahmad N, Kumar N, Bhatnagar A, Int. J. Pharm., 477, 601 (2014)

[11] Choi WS, Cho HI, Lee HY, Lee SH, Choi YW, J. Pharm. Invest., 40, 373 (2010)

[12] Pardeike J, Hommoss A, Muller RH, Int. J. Pharm., 366, 170 (2009)

[13] Muller RH, Radtke M, Wissing SA, Int. J. Pharm., 242, 121 (2002)

[14] Beloqui A, Solinis MA, Rodriguez-Gascon A, Almeida AJ, Preat V, Nanomedicine, 12, 143 (2016)

[15] Zhao X, Mei W, Gong M, Zuo W, Bai H, Dai H, Molecules, 169, 775 (2011)

[16] Zhang X, Yeung ED, Wang J, Panzhinskiy EE, Tong C, Li W, Li J, Clin. Exp. Pharmacol. Physiol., 37, 841 (2010)

[17] Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S, J. Agric. Food Chem., 51, 1201 (2003)

[18] Kim SC, Byun SH, Yang CH, Kim CY, Kim JW, Kim SG, Toxicology, 197, 239 (2004)

[19] Zhang XY, Qiao H, Ni JM, Shi YB, Qiang Y, Eur. J. Pharm. Sci., 49, 411 (2013)

[20] Kim SJ, Kwon SS, Jeon SH, Yu ER, Park SN, Int. J. Cosmet. Sci., 36, 553 (2014)

[21] Jeon SH, Yoo CY, Park SN, Colloids Surf. B: Biointerfaces, 129, 7 (2015)

[22] Kwon SS, Kim SY, Kong BJ, Kim KJ, Noh GY, Im NR, Lim JW, Ha JH, Kim J, Park SN, Int. J. Pharm., 483, 26 (2015)

[23] Kwon SS, Kong BJ, Park SN, Eur. J. Pharm. Biopharm., 92, 146 (2015)

[24] Jeong YM, Ha JH, Park SN, J. Ind. Eng. Chem., 35, 54 (2016)

[25] Teeranachaideekul V, Boonme P, Souto EB, Muller RH, Junyaprasert VB, J. Control. Release, 128, 134 (2008)

[26] Jores K, Mehnert W, Drechsler M, Bunjes H, Johann C, Mader K, J. Control. Release, 95, 217 (2004)

[27] Fang JY, Fang CL, Liu CH, Su YH, Eur. J. Pharm. Biopharm., 70, 633 (2008)

[28] Muller RH, Jacobs C, Kayser O, Adv. Drug Deliv. Rev., 47, 3 (2001)

[29] Rodrigues LR, J. Colloid Interface Sci., 449, 304 (2015)

[30] Ranpise NS, Korabu SS, Ghodake VN, Colloids Surf. B: Biointerfaces, 116, 81 (2014)

[31] Kuo YC, Chen HH, Int. J. Pharm., 365, 206 (2009)

[32] Gaur PK, Mishra S, Verma A, Verma N, J. Exp. Nanosci., 11, 38 (2016)

[33] Shah R, Eldridge D, Palombo E, Harding I, SpringerInternational Publishing (2015).

[34] Kovacevic A, Savic S, Vuleta G, Muller RH, Keck CM, Int. J. Pharm., 406, 163 (2011)

[35] Han SB, Kwon SS, Jeong YM, Yu ER, Park SN, Int. J. Cosmet. Sci., 36, 588 (2014)

[36] Li B, Liu B, Li J, Xiao H, Wang J, Liang G, Int. J. M. Sci., 16, 17999 (2015)

[37] Neupane YR, Srivastava M, Ahmad N, Kumar N, Bhatnagar A, Kohli K, Int. J. Pharm., 477, 601 (2014)

[38] Shamma RN, Aburahma MH, Int. J. Nanomedicine, 9, 5449 (2014)

[39] Pradhan M, Singh D, Singh MR, Chem. Phys. Lipids, 186, 9 (2015)

[40] Chen H, Wang Y, Zhai Y, Zhai G, Wang Z, Colloids Surf. A: Physicochem. Eng. Asp., 465, 130 (2015)

[41] Souto EB, Wissing SA, Barbosa CM, Muller RH, Int. J. Pharm., 278, 71 (2004)

[42] Zhai Y, Zhai G, J. Control. Release, 193, 90 (2014)