Oleic Acid Incorporated Gemcitabine-Eluting Stents for Treatment of Cholangiocarcinoma

Jeongdeok Seo; Jonghwan Lee; Kun Na

Macromolecular Research, Vol.25, No.1, 63-69, January, 2017

DOI10.1007/s13233-017-5010-3 Export Citation

Oleic Acid Incorporated Gemcitabine-Eluting Stents for Treatment of Cholangiocarcinoma

Jeongdeok Seo, Jonghwan Lee, and Kun Na^†

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi 14662, Korea

E-mail:

One of the major issues in cholangiocarcinoma (CC) treatment is bile duct occlusion-associated symptoms. As an alternative way of surgical excision of a CC, drug-eluting stents (DESs) have developed to treat both CC and occlusion. Gemcitabine (Gem) is effective for treatment of CC, however, it has limited applicability to use in DES because of its hydrophilic property. To solve these problems, we developed stent coating membrane (PTOA10-Gem) consisted of Gem, oleic acid (OA), and pellethane (PT). PTOA10-Gem membranes were additionally coated with PT to minimize rapid initial burst and washout of water-soluble Gem. OA was incorporated as a tissue penetration enhancer, and successfully achieved enhanced Gem penetration into cancer cell sheet (5.25-fold) and mouse skin (3-fold). Moreover, PTOA10-Gem led to dramatic decrease in tumor volume by 45% for 9 days. These findings suggest that the OA incorporated PT membrane is effective to improve a therapeutic efficacy of hydrophilic drug-eluting stents to treat CC, as well as other non-vascular cancers.

Keywords:drug eluting stent;penetration enhancer;cholangiocarcinoma;gemcitabine;therapeutic effect

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[Referenced By]

[1] Vauthey JN, Blumgart LH, Semin. Liver Dis., 14, 109 (1994)

[2] Kuwayti K, Baggenstoss AH, Stauffer MH, Priestley JT, Surg. Gynecol. Obstet., 104, 357 (1957)

[3] Khan SA, Davidson BR, Goldin R, Pereira SP, Rosenberg WMC, Taylor-Robinson SD, Thillainayagam AV, Thomas HC, Thursz MR, Wasan H, Gut, 51, vi1 (2002)

[4] Lee DK, J. Hepatobiliary Pancreat. Surg., 16, 628 (2009)

[5] Seo J, Lee J, Na K, J. Pharm. Investig., 46, 3171 (2016)

[6] Penz C, Kornek GV, Raderer M, Ulrich-Pur H, Fiebiger W, Lenauer A, Depisch D, Krauss G, Schneeweiss B, Schneeweiss W, Ann. Oncol., 12, 183 (2001)

[7] Chung MJ, Kim H, Kim KS, Park S, Chung JB, Park SW, J. Gastroenterol. Hepatol., 27, 261 (2012)

[8] Gontero P, Frea B, Ann. Oncol., 17, 123 (2006)

[9] Plunkett W, Huang P, Xu YZ, Heinemann V, Grunewald R, Gandhi V, Semin. Oncol., 22, 4 (1995)

[10] Pili B, Bourgaux C, Meneau F, Couvreur P, Ollivon PM, J. Therm. Anal. Calorim., 98, 19 (2009)

[11] Lee JW, Yang SG, Na K, Int. J. Pharm., 427, 276 (2012)

[12] Benet LZ, Kroetz D, Sheiner L, Hardman J, Limbird L, in Goodman and Gilman's the Pharmacological Basis of Therapeutics, McGraw-Hill, New York, 1996, p 3.

[13] Arya G, Vandana M, Acharya MS, Sahoo SK, Nanomedicine, 7, 859 (2011)

[14] Pasut G, Canal F, Via LD, Arpicco S, Veronese, Schiavon MFO, J. Control. Release, 127, 239 (2008)

[15] Cavallaro G, Mariano L, Salmaso S, Caliceti P, Gaetano PG, Int. J. Pharm., 307, 258 (2006)

[16] Ali SM, A. R., M. U. Ahmad, Chen, Sheikh PS, Ahmad SI, Bioorganic Med. Chem. Lett., 15, 2571 (2005)

[17] Chiou GC, Chuang CY, J. Pharm. Sci., 78, 815 (1989)

[18] Antoyo S, Arellano A, Ygartua P, Martin C, Int. J. Pharm., 117, 219 (1995)

[19] Davis SS, Illum L, Clin. Pharmacokinet., 42, 1107 (2003)

[20] Senel S, Hincal AA, J. Control. Release, 72, 133 (2001)

[21] Richardson JL, Illum L, Thomas NW, Pharm. Res., 9, 878 (1992)

[22] Yamamoto A, Hayakawa E, Kato Y, Nishiura A, Lee VH, J. Pharmacol. Exp. Ther., 263, 25 (1992)

[23] Pathan IB, Setty CM, Trop. J. Pharm. Res., 8, 173 (2009)

[24] Trommer H, Neubert RHH, Skin Pharmacol. Physiol., 19, 106 (2006)

[25] Santoyo S, Arellano A, Ygartua P, Martin C, Int. J. Pharm., 117, 218 (1995)

[26] Goldenm GM, McKie JE, Potts RO, J. Pharm. Sci., 76, 25 (1987)

[27] Francoeur ML, Golden GM, Potts RO, J. Pharm. Sci., 76, 25 (1978)

[28] Goodman M, Barry BW, J. Pharm. Pharmacol., 38, 71 (1986)

[29] Gay CL, Murphy TM, Hadgraft J, Kellaway IW, Evans JC, Rowlands CC, Int. J. Pharm., 49, 39 (1989)

[30] Kandimalla K, Kanikkannan N, Andega S, Singh M, J. Pharm. Pharmacol., 51, 783 (1999)

[31] Babu RJ, Chen L, Kanikkannan N, in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement, Springer, Berlin Heidelberg, 2015, p 133.

[32] Phillips RM, Loadman P, Cronin B, Br. J. Cancer, 77, 2112 (1998)

[33] Cooper ER, Merritt EW, Smith RL, J. Pharm. Sci., 74, 688 (1985)

[34] Naik A, Pechtold LA, Potts RO, Guy RH, J. Control. Release, 37, 299 (1995)

[35] Williams AC, Barry BW, Adv. Drug Deliv. Rev., 64, 128 (2012)

[36] Lampe MA, Burlingame AL, Whitney LA, Williams J, Brown ML, Roitman EBE, Elias PM, J. Lipid Res., 24, 120 (1983)

[37] Boelsma E, Tanojo H, Bodde HE, Ponec M, Toxicol. In Vitro, 10, 728 (1996)

[38] Jiang J, Wang RK, Phys. Med. Biol., 49, 5283 (2004)

[39] Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI, Cancer Res., 64, 6304 (2004)

[40] Moon S, Yang SG, Na K, Biomaterials, 32, 3603 (2011)

[41] Min D, Jeong D, Choi MG, Na K, Biomaterials, 52, 484 (2015)

[42] Chung MJ, Kim H, Kim KS, Park SKS, Chung JB, Park SW, J. Gastroenterol. Hepatol., 27, 261 (2012)

[43] Acharya G, Park K, Adv. Drug Deliv. Rev., 58, 387 (2006)

[44] Alves MM, Vieira JM, Pereira RA, Pereira MA, Mota M, Water Res., 35, 264 (2001)

[45] Kuh HJ, Jang HS, Wientjes MG, Weaver GMJR, Au JLS, J. Pharmacol. Exp. Ther., 290, 871 (1999)

[46] Xiong Z, Kapral FA, J. Med. Microbiol., 37, 192 (2015)