Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed

Dong-Hoon Lim; Dubok Choi; Sun-Mi Kim; YuLan Piao; On-You Choi; Geum-Sook Lim; Young-Cheol Chang; Hoon Cho

Korean Journal of Chemical Engineering, Vol.34, No.3, 787-796, March, 2017

DOI10.1007/s11814-016-0335-8 Export Citation

Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed

Dong-Hoon Lim, Dubok Choi¹, Sun-Mi Kim², YuLan Piao², On-You Choi³, Geum-Sook Lim⁴, Young-Cheol Chang⁵, and Hoon Cho^{2, †}

Department of Urology, School of Medicine, Chosun University, Gwangju 61452, Korea
¹Biotechnology Laboratory, B-K Company Ltd., Jeonbuk 54008, Korea
²Department of Biochemical Polymer Science & Engineering, Chosun University, Gwangju 61452, Korea
³Biochem Lab., Shinchon E&C R&D, Gwangju 61165, Korea
⁴Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, Gwangju 61186, Korea
⁵Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan

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The hypolipidemic and antioxidant effects of dietary supplementation with polysaccharide isolated from Salicornia bigelovii seed (SBS) were evaluated in hypercholesterolemic rats. Following administration of SBS polysaccharide at 200mg/kg BW/day (HPS group), total cholesterol (TC), and low density lipoprotein cholesterol (LDLC) levels were 32.45% and 58.09% lower than those in negative controls (NC) group, respectively. However, in the case of high density lipoprotein cholesterol (HDLC), it was 36.37% higher than that of NC group. The arteriosclerosis and cardiac risk indices were 64.23% and 50.53% lower than in the NC group. However, the HTR (HDLC/TC) value was higher 2.05-fold than that of the NC group. Hydroxy-3-methylglutaryl CoA reductase activity in HPS group was 55.1% lower than that of the NC group. Activities of alanine transferase, aspartate aminotransferase, and alkaline phosphatase in HPS group were 29.71%, 26.49%, and 32.24%, lower than that of the NC group. SOD, CAT, and GSH-Px activities in HPS group were 31.05%, 49.29%, and 54.62% higher than that of the NC group. These results indicate that SBS polysaccharide has both hypolipidemic and antioxidant effects and shows potential for ameliorating hypercholesterolemia.

Keywords:Hypolipidemic Activity;Antioxidant Activity;Polysaccharide;Salicornia bigelovii Seed

[References]

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[2] Farooq A, Bhanger MI, Khall M, Nasir A, Sarwat I, J. Agric. Food Chem., 50, 4210 (2002)

[3] Kang S, Kim D, Lee BH, Kim MR, Chiang MH, Hong JG, Food Sci. Biotechnol., 20, 115 (2011)

[4] Rhee MH, Park HJ, Cho JY, J. Med. Plant Res., 3, 548 (2009)

[5] Shin KS, Boo HO, Jeon MW, Ko JH, Korean J. Plant. Res., 15, 216 (2002)

[6] Song HS, Kim DP, Jung YH, Lee MK, Kor. J. Food Nutr., 20, 150 (2007)

[7] Kang SM, Kim DR, Lee BH, Kim MR, Choang MH, Ho JG, Food Sci. Biotechnol., 20, 115 (2011)

[8] Sung JH, Park SH, Seo DH, Lee JH, Hong SW, Hong SS, Biosci., Biotechnol., Biochem., 73, 552 (2009)

[9] Jung BM, Park JA, Bae SJ, J. Kor. Soc. Food Sci. Nutr., 37, 148 (2008)

[10] Jo YC, Ahn JH, Chon SM, Lee KS, Bae TJ, Kang DS, Kor. J. Medicinal Crop. Sci., 10, 93 (2002)

[11] Kang HK, Koppula SH, Park TK, Tropical J. Pharmaceutical Res., 12, 897 (2013)

[12] Wang QZ, Liu XP, Shan Y, Cuan FQ, Chen Y, Wang XY, Wang M, Feng X, Fitoterapia, 83, 742 (2012)

[13] Glenn EP, Brown J, O’Leary J, Scientific American Inc., 76 (1998)

[14] Lu DH, Zhang M, Wang SJ, Cai JL, Zhou X, Zhu CP, LWT Food Sci. Technol., 43, 519 (2010)

[15] Choi OY, Choi DB, Park CB, Oh BI, Cho HJ, Jeong HRS, Korea Patent, 10-1022137 (2011).

[16] Choi OY, Choi DB, Park CB, Oh BI, Ha BS, Kim HJ, Noh YH, Cho HJ, Jeong HRS, Korea Patent, 10-1022133 (2011).

[17] Choi D, Lim GS, Piao YL, Choi OY, Cho KA, Park CB, Chang YC, Song YI, Lee MK, Cho H, Korean J. Chem. Eng., 31(12), 2221 (2014)

[18] Hulcher FH, Olesson WH, Am. J. Lipid Res., 14, 625 (1987)

[19] Gillies PJ, Rathge KA, Robinson CS, Experi. Mol. Pathology, 44, 329 (1986)

[20] Im SA, Kim KJ, Lee CK, Inter. Immunopharmacol., 6, 1451 (2006)

[21] Ryu DS, Kim SH, Seok DS, Food Sci. Biotechnol., 18, 1481 (2009)

[22] Lee KY, Lee MH. Chang IY, Yoon SP, Lim DY, Jeon YJ, J. Ethnopharmacol., 103, 372 (2006)

[23] Lee MY, Kim KH, Kim YH, Lee DS, Kor. J. Microbiol. Biotechnol., 36, 43 (2008)

[24] Ryu DS, Kim SH, Lee DS, J. Microbiol. Biotechnol., 19, 1482 (2009)

[25] Wang Y, Yang Z, Wie X, Int. J. Biol. Macromol., 47, 534 (2010)

[26] Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, Ramesh B, Rao CA, Food Chem. Toxicol., 48, 1078 (2010)

[27] Goldstein JL, Brown MS, J. Med., 58, 147 (1975)

[28] Yoshino G, Kazurri T, Kasama T, Iwai M, Iwataris I, Matsuba K, Matsusshita M, Baba S, Atherosclerosis, 73, 191 (1988)

[29] Qureshi AA, Diz ZZ, Abuirmeileh N, Bugger CC, Ahmad Y, Elson CEJ, Nutri., 113, 1746 (1983)

[30] Konjufca VH, Pesti GM, Balkali RI, Poultry Sci., 76, 1264 (1997)

[31] Evans J, Hood RL, Oakenfull DG, Sidhu GS, Br. J. Nutr., 68, 217 (1992)

[32] Cheung PCK, Nutr. Res., 16, 1953 (1996)

[33] Bocan TMA, Mueller BS, Uhendrof PD, Newton RS, Kraus BR, Arteriosclerosis Thrombosis, 11, 1830 (1991)

[34] Lee HJ, Choi MS, J. Food Sci. Nutr., 4, 344 (1998)

[35] Kupeli E, Orhan DD, Yesilada E, J. Ethnopharmacol., 103, 455 (2006)

[36] Yamaguchi M, Yamaguchi R, Biochem. Pharmacol., 35, 773 (1986)

[37] Jain KS, Kathiravan MK, Somani RS, Shishoo CJ, Bioorg. Med. Chem. Lett., 15, 4674 (2007)

[38] Tomas M, Latorre G, Senti M, Marrugat J, Revista Espanola de Cardiologia, 57, 557 (2004)

[39] Ohara Y, Peterson TE, Harrison DG, J. Clinical Investigation, 91, 2546 (1993)

[40] Devi gs, Prasad MH, Saraswathi I, Raghu D, Rao DN, Reddy PP, Clin. Chim. Acta, 293, 53 (2000)

[41] Harman D, Proc. Natl. Acad. Sci., 88, 5360 (1991)

[42] Pompella A, Visvikis A, Paolicchi A, Tata V, Casini AF, Biochem. Pharmacol., 66, 1499 (2003)

[43] Aragao MOD, Guarize L, Lanini J, Costa CJ, Garcia RMG, Scio E, J. Ethnopharmacol., 128, 629 (2010)

[44] Kwon MJ, Joun YS, Song YO, J. Korean Soc. Food Nutr., 23, 899 (1994)