AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by beta 1-Integrin-Mediated Signaling

Li Y; Shi XL; Tian L; Sun HY; Wu YJ; Li X; Li JJ; Wei YJ; Han XX; Zhang J; Jia XW; Bai R; Jing LM; Ding P; Liu HL; Han D

Advanced Materials, Vol.28, No.46, 10230-10235, 2016

DOI10.1002/adma.201603027 Export Citation

AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by beta 1-Integrin-Mediated Signaling

Li Y, Shi XL, Tian L, Sun HY, Wu YJ, Li X, Li JJ, Wei YJ, Han XX, Zhang J, Jia XW, Bai R, Jing LM, Ding P, Liu HL, Han D

A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate beta 1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.