Three nanocubic Ag/CexNd1-xO2 catalysts were synthesized to evaluate the influence of Nd doping on catalyst practicability. It was observed that Nd doping generated excessive ceria surface oxygen vacancies, but reduced the bulk oxygen vacancies. These variations in oxygen vacancies suppress the utilization of ceria bulk oxygen, and induce the formation of less active O-2(-) species instead of O-2(-), resulting in a low soot oxidation activity. However, the introduction of Nd can inhibit Ag sintering and thus enhance the catalysts' thermal stability effectively. As a consequence, Ag/Ce0.95Nd0.05O2 nanocubes make a good balance between the catalyst activity and stability. Moreover, it was observed that catalyst deactivation during soot oxidation becomes more obvious when the catalysts and soot are not in close contact. (C) 2016 Elsevier B.V. All rights reserved.