As described by Environment and Climate Change Canada,([1]) the Prohibition of Certain Toxic Substances Regulations, 2012 developed under the Canadian Environmental Protection Act, 1999 are a multi-substance risk management instrument used to prohibit the manufacture, use, sale, offer for sale or import of certain toxic substances and products containing these substances with a (limited) number of exemptions. The substances currently prohibited by these regulations have been declared toxic to the environment and/or human health; are generally persistent, bioaccumulative, and/or inherently toxic as per the Act; and tend to be used in industrial applications. The Regulations are amended from time to time to add substances for which prohibition has been deemed appropriate, or to amend existing controls when necessary. Compliance with the requirements of the Regulations is mandatory and the provisions apply to every person or company in Canada, unless otherwise noted. This article summarizes the prohibitions, exemptions, and key features of the Prohibition of Certain Toxic Substances Regulations, 2012, including permitting provisions, reporting and record-keeping, as well as considerations for compliance.