Bubble dispersion characteristics play an important role in heat and mass transfer of bubble-liquid two-phase turbulent flows in bubble-column reactors. In order to quantitatively describe the influence of operation conditions and sparger design on two-phase turbulent hydrodynamics in terms of a computational fluid dynamics approach, a second-order moment bubble-liquid two-phase turbulent model was developed to predict the effects of superficial gas velocity, liquid and gas density, liquid dynamic viscosity, and sparger nozzle configuration on bubble-liquid hydrodynamics, e.g., bubble volume fraction, turbulent kinetic energy, and turbulent kinetic energy dissipation. Bubble dispersion behavior was found to be a complex function of industrial operations and sparger configuration parameters.