With an identical temperature profile, various cure pressures were applied to determine the effect of cure pressure on void distribution and interlaminar shear strength (ILSS) of [0](10) T800/X850 composite laminate. Void shape, distribution, and void content within the composite laminates were characterized using optical microscope. The ILSS was evaluated using short-beam three-point bending tests and their interface debonding failure and fracture surfaces were determined using scanning electron microscope. The experimental results indicated that long strips voids are generated in the low-pressure curing stage. The voids mainly exist in the two forms of rod-like shape and spherical shape, and their number and size decrease as the cure pressure increases. The influence of cure pressure on the void content and ILSS shows a different trend in two stages: when the cure pressure is lower than 0.4MPa, the ILSS decrease by 5.21% with 1% increase in void content, and their relationship is inversely linear. However, when the cure pressure is higher than 0.4MPa, the void content is less than 1% and ILSS increase slightly by 1.69% when the cure pressure goes from 0.4 to 0.6MPa, the influence of cure pressure on void content and ILSS is clearly presented.