Poisoning of Pt/C catalysts due to SO2 on a rotating disk electrode (RDE), and as part of the cathode layer in a single cell fuel cell and fuel cell stack are studied in terms of the system performance, and the effect of electrochemical and chemical post treatment to remove the adsorbed sulphur-containing species. It is found that external polarisation can only recover the ORR performance of catalyst on an RDE after SO2 poisoning when an applied potential of 1.6 V(RHE) is used for 1 ks. An alternative approach is to use ozone, as in the presence of this species, the electrode potential is raised to similar to 1.6V(RHE) due to the high potential of the ozone reduction reaction. The high open circuit potential leads to a mixed potential and was found also to be highly efficient at removing the poison via coupled ozone reduction and poison oxidation. The ozone process is found to work efficiently at the catalyst level as shown through rotating disk electrode studies and also in single cell fuel cells. Furthermore we demonstrate for the first time the recovery of a SO2 poisoned fuel cell stack using the mixed-potential approach and ozone as a reactant. The cleaning process is fast (similar to 10 minutes), occurs at room temperature, and does not require any special modification to the fuel cell. The process may be applicable to a wide range of poisons which can be oxidatively removed from platinum at high potentials. (C) 2016 The Author(s). Published by Elsevier Ltd.