A significant portion of crude oil remains in the reservoir after the application of conventional recovery. To meet the growing demand of energy, enhanced oil recovery (EOR) methods should be used efficiently to recover the extra amount of trapped crude oil after secondary water flooding. Surfactant flooding is one of the chemical EOR methods that can be implemented to recover oil from the remaining oil in place. Ionic liquids (ILs), which are salts with a melting point beneath 100 degrees C, were considered as a prospective alternative to the surfactant because of their superiority in different points. In this paper, three flooding experiments using Berea sandstone samples were conducted using IL solution (commercially called Ammoeng 102) in different scenarios to check its recovery efficiency. In the first scenario, a core sample was saturated with crude oil up to irreducible water saturation (Swir) and then secondary flooded with brine. IL solution was followed in tertiary flooding mode. The second scenario was implemented by injecting a slug of IL solution [0.4 pore volume (PV)] chased with brine in the secondary flooding stage. Continuous secondary flooding with IL solution from the beginning to the end of experiment was used to carry out the third scenario. The experimental runs were simulated using the surfactant flood model (SFM) available in CMG STARS software. All three scenarios were successfully simulated, and a good match was obtained for oil recovery, well bottom-hole pressure, and imbibition relative permeability curves. Both simulation and experimental results proved the superiority of secondary continuous IL solution flooding, providing the highest oil recovery [71% original oil in place (OOIP)] compared to 64% OOIP for the secondary flooding of 0.4 PV IL solution slug. Tertiary IL solution flooding consequent to secondary water flood was able to recover 48% OOIP. Experimental contact angle measurements and the shift in relative permeability curves indicate that wettability alteration toward more water-wet characteristics is the main recovery mechanism for ionic liquid flooding.