The liquid-to-air membrane energy exchanger is a novel membrane base energy exchanger that allows both heat and moisture transfer between air and a salt solution using a membrane. The heat and mass transfer performance of a single one is significantly dependent on two dimensionless parameters: number of heat transfer units and the ratio of heat capacity rates between solution flow and airflow (Cr-*). In this study, the effectiveness of a small-scale liquid-to-air membrane energy exchanger under low Cr-* conditions (i.e., Cr-*<1) that has been not investigated previously is experimentally and numerically tested.