This research deals with computational modelling of non-reactive and reactive turbulent spray processes. The spray process is modelled using the Euler Eulerian multiphase approach together with a size-of-classes model where the discrete phase is considered as continuum and divided into sub-classes. The combustion process is modelled by taking into account chemical kinetics and solving homogeneous gas phase reactions. The combustion model is implemented into a commercial computational fluid dynamics code, and used in combination with previously validated spray sub-models. Several non-reactive cases are modelled by comparing the fuel spatial and temporal development to the available experimental data. The modelled results show excellent agreement for fuel penetration and mixture distributions. Furthermore, the developed method is validated by modelling reactive spray processes within constant volume vessel, and by comparing results to the Engine combustion network experimental data. The vessel conditions correspond well to diesel-like conditions in terms of gas residuals, pressure and temperature. Finally, the given results show a good agreement for the lift-off length and the ignition delay trends compared to the experimental data, but a slight discrepancy in the combustion process occurrence is observed. (C) 2016 Elsevier Ltd. All rights reserved.