The orientation dependence of the CF3* formation was investigated for two collisional energy transfer reactions, CF3Cl + Ar(P-3) and CF3Br + Kr(P-3), and the results were compared with that of a related CF3H + Ar(P-3) reaction which was previously studied. For the three systems studied, the reactivity was found to be the greatest for collisions at the CF3 end of the molecules. The CF3Cl + Ar(P-3) system exhibited a steric opacity function with two reactive sites. The CF3Br + Kr(3P) system showed a broad steric opacity function as compared with the other two systems. This broadness of the steric opacity function is discussed in terms of the effect of the center-of-mass shift in the molecular frame and/or of impact parameter broadness.