The polymorphism of isotactic polypropylene (iPP) in combination with the strong response of this polymer to nucleation can be utilized for expanding the application range of this versatile polymer. Based on three "case studies" related to beta-iPP pressure pipes, ethylene-propylene (EP) random copolymers for thin-wall injection molding and transparency and sterilization resistance of cast films we demonstrate ways of combining polymer composition, nucleation and process settings to achieve the desired application performance. The importance of considering interactions between polymer design, nucleation and processing parameters for designing application properties is highlighted.