Naringin dihydrochalcone (naringin DC) is an intense sweetener and a strong antioxidant with potential applications in many food and pharmaceutical products. However, the poor solubility and stability of naringin DC in aqueous systems at room temperature severely limits its applications in these areas. The solubility of naringin dihydochalone was quantified in water, ethyl acetate, binary solvent mixtures of methanol + water and ethanol + water by a synthetic method at different temperatures. The solubility of naringin DC in a given solvent increases with the rising temperature. The experimental data were well correlated with an Apelblat equation and Universal Quasichemical model. Moreover, the physical properties and crystal habit of naringin DC were discussed through a thermogravimetric analyzer, a differential scanning colorimeter, and a scanning electron microscope.