The development and design of the crystallization process strongly depend on accurate solid liquid equilibrium data. In this paper, the solubility data of amorphous cefmetazole sodium in pure solvents (ethanol, n-propanol, i-propanol, n-butanol, n-amyl alcohol, ethyl acetate, n-butyl acetate, n-hexane, and cyclohexane) and binary solvent mixtures (methanol and ethanol) were measured by using the UV spectroscopic method and gravimetrical method, respectively, at temperatures from 278.15 to 313.15 K. The results show that the solubility data of cefmetazole sodium increase with the increasing temperature in all investigated solvents and decrease with the rise of the mole fraction of ethanol in the binary solvent mixtures. The Apelblat equation was successfully used to correlate the experimental solubility data in pure solvents, and the Apelblat equation, the CNIBS/R-K model, and the Jouyban-Acree model were successfully applied to correlate the solubility data in methanol + ethanol systems. It was found that the correlated data are in good agreement with the experimental data. Additionally, the molecular surface electrostatic potential (MSEP) correlated with the solubility data was also calculated and used to explain the difference of the solubility data of amorphous cefmetazole sodium in various solvents.