The solubilities of 4',5,7-triacetoxyflavanone in eight different alcohols, 2-methoxyethanol, 2-propoxyethanol, 2-butoxyethanol, ethyl acetate, tetrahydrofuran, and acetone have been measured with an HPLC (high-performance liquid chromatography) analysis method at the experimental temperature from 278.2 to 318.2 K. The solubilities of 4',5,7-triacetoxyflavanone in selected solvents increase with an increasing of temperature. The solubilities of 4',5,7-triacetoxyflavanone were correlated with the modified Apelblat equation and universal quasichemical (UNIQUAC) equation, respectively. The correlated solubilities were in good accordance with the measured data at the experimental temperature. Furthermore, the crystal habits of 4',5,7-triacetoxyflavanone in selected solvents were studied in this work.