Here, we report on the.photochemical,deposi, tion of Rhodamine 6G (Rh6G) and Alexa647 molecules from aqueous and methanolic solution along 180 degrees ferroelectric (FE) domain walls (DWs) of z-cut lithium niobate (LNO) single crystals. Molecules and FE domains were investigated by means of dynamic-mode AFM, piezoresponse force microscopy (PFM), and confocal scanning-fluorescence microscopy. A high deposition affinity for 180 DWs on the LNO surface is observed, leading to the formation of molecular nanowires. Additionally, a more complex depoSition pattern for Rh6G adsorbed to the domain areas of freshly poled-samples was equally observed, being associated with the DW dynamics. These results are explained by considering contributions from screening-charge-dependent photochemistry as confined to the DWs, UV-induced DW motion, and transient electrostatic fields arising from the metastable defect diStribution shortly after poling. Hence, tuning these effects offers the possibility for accurately controlling the complex bottom-up assembly of functional, molecular nanostructures through domain-structured ferroelectric templates.