In the present study, Ag nanoparticles decorated Mn2O3 hybrid nanofibers were fabricated by calcination of electrospun PVP/AgNO3/Mn(NO3)(2) precursor nanofibers and characterized by FESEM, EDS, XRD, TEM. It was found that the prepared hybrid nanofibers included tiny Ag nanoparticles (from several to 15 nm) distributed uniformly in the Mn2O3 matrix. The investigation of bactericidal activity towards gram positive and gram-negative bacteria showed that Ag/Mn2O3 hybrid nanofibers could exhibit enhanced efficiency than that of bare Mn2O3 nanofibers. Therefore, this result suggests that the as prepared Ag/Mn2O3 hybrid nanofibers can be a promising nanomaterial as a good alternative for the development of new bactericides. (C) 2016 Elsevier B.V. All rights reserved.