화학공학소재연구정보센터
Molecular Crystals and Liquid Crystals, Vol.627, No.1, 210-219, 2016
Nanomaterials with antioxidant properties, obtained via biotechnology, using the solid state biosynthesis
Two nanomaterials type emulsion (EP and EM), that includes two different bioactive metabolites of Monascus sp. were obtained. Prior obtaining the nanoemulsion, tha enatural extracts, P (Monascus sp.1 - parental strain) and M (Monascus sp.2 - modified strain), were conditioned in order to increase their stability and biodisponibility. The new nanomaterials obtained were tested in terms of physical and chemical characteristics, by dynamic light scattering, infrared spectra and thermal analysis. Biological properties was investigated, by determining the effects of these new bio materials on wound healing and by measuring the antioxidant properties. The results obtained reveal the presence of aggregates with dimensions in the range of 1-100 nm, proving that these bio-products are nano materials. The infrared spectra indicate the presence of benzene metadisubstituted (bands at 881.25 cm(-1) and 880.4 cm(-1) respectively), which are specific to Monascus metabolites Thermal analysis indicate the similarities between the matrix used in conditioning and the final nano products contains Monascus metabolites. The influence of these nano bio products on cicatrisation process was determined by tests on mices. It was concluded that there is small positive effect of the extracellular EP product. In this case, the bio product increase with 3% the rate of cicatrisation process, in comparison with the witness. All the two nano products show a significant antioxidant properties, with specific quenching rate of 97.7%