A novel chalconyl ester homologous series of liquid crystals has been synthesized and studied with a view to understanding and establishing the effect of molecular structure on liquid crystalline properties. Novel series consisted of 13 members (C-1-C-18) of a series. C-1-C-4 member of a series is nonliquid crystals and, the rest of the homolog members (C-5-C-18) are enantiotropically nematogenic with absence of smectogenic property. None of the homolog is monotropically mesomorphic. Transition and melting temperatures were determined by an optical microscope equipped with a heating stage. Textures of nematic phase are threaded or schlieren. Spectral and analytical data of selected members of a series confirms the molecular structures of homologues. Cr-N and N-I transition curves of a phase diagram behaved in normal manner with exhibition of odd-even effect of very short range as observed for N-I transition curve. Thermal stability for nematic is 122.0 degrees C and the nematogenic mesophase ranges from 7.0 degrees C to 38.0 degrees C. Liquid crystal properties of a present series are compared with the structurally similar known homologous series.