Information about current advances in the field of multisensory systems based on ion exchange membranes for analysis of multicomponent aqueous-organic media of various assignments is summarized. The most promising membrane nanomaterials for chemical sensors are considered. The possibilities for directed variation of characteristics of chemical sensors via modification of perfluorosulfonic cation exchange membranes are analyzed. Particular attention is given to investigations concerning the determination of biologically active compounds in polyionic solutions at different pH values.