Composite particles of titania/silica/ natural rubber (TiO2/SiO2/NR) were prepared and evaluated for their potential antibacterial application. All processes were restricted to a low temperature or a small heating contact time to avoid degradation of the NR. The primary NR particles were synthesized by spray drying and then SiO2 and TiO2 were incorporated sequentially by chemical vapor deposition and liquid phase deposition, respectively. The physical and chemical properties were characterized by X-ray diffractometry, scanning electron microscopy with energy dispersive X-ray spectrometry, Fourier- infrared spectroscopy and thermogravimetric analyses. The TiO2/SiO2/NR composite particles had a spherical shape with a diameter of about 10 lm, with titania on the outer layer, and showed an effective antibacterial activity of a 99.99% reduction in viable Escherichia. coli and Staphylococcus aureus within 20 min of exposure under fluorescent light. In addition, the particles could be reused with the same level of antibacterial activity for up to three cycles. The structural and antibacterial models of the composite particles are proposed in this work. (C) 2017 The Society of Powder Technology Japan. Published by Elsevier B. V. and The Society of Powder Technology Japan. All rights reserved.