Jatropha de-oiled seed cake was explored to utilize as a basic nutrient source for Candida parapsilosis, isolated from poultry garbage and selected based on the production of lipase and phytase enzymes under submerged fermentation. At optimized parameters under solid-state fermentation, lipase and phytase activities were recorded as 1056.66 +/- 2.92 and 833 +/- 2.5 U/g of substrate ( U/g), respectively. Besides enzyme production, complete elimination of phorbol esters and significant phytate reduction from 6.51 +/- 0.01 to 0.43 +/- 0.01 g/100 g of seed cake were noted after 3 days incubation. Curcin and trypsin inhibition activity were reduced significantly from 26.33 +/- 0.43 to 0.56 +/- 0.02 mg/100 g and 229.33 +/- 2.02 to 11.66 +/- 0.28 U/g, respectively after 5 days incubation. Saponins were reduced from 5.56 +/- 0.19 to 1.95 +/- 0.01 g/100 g of seed cake after 7 days incubation. (C) 2016 Elsevier Ltd. All rights reserved.