Industrial natural gas treating plants commonly employ amine-based treatments for hydrogen sulfide elimination from crude oil and gas. Some deficiencies boost the motivation to find an appropriate alternative. Due to their advantageous properties, liquid electrolytes are considered as possible substitutes for classical alkanolamine solvents in such processes. The solubility of gases in ionic solutions at different temperatures and pressures is a crucial factor in the examination of ionic liquids as a potential alternative. Two intelligent methods, namely, simple multi-layer perceptron (MLP) and radial basis function neural networks, are proposed to accurately predict the solubility of H2S in various ionic liquids. The predicted values agree well with the experimental data. A comparison to other intelligent models, which were recently suggested, reveals the superiority of the proposed simple MLP model.