Membrane selection is a crucial step that will affect the economic feasibility of the membrane water treatment process. A comprehensive evaluation consisting of Verbeme Cost Model, assessment of membrane performance and fouling propensity, osmotic pressure differential (OPD) and specific energy consumption (SEC) was employed to determine the potential of nanofiltration (NF 270, NF 90 and TS 80) and low pressure reverse osmosis (XLE) membranes to be used in brackish water desalination process. The aim was to save costs by replacing the typical brackish water reverse osmosis (BW 30) membrane. Verbeme Cost Model showed that higher flux NF membranes resulted in lower overall costs. However, after assessing the membrane performance, NF 270 and TS 80 were excluded due to their high fouling propensity and their failure to reduce total dissolved solids (TDS) in the solution. Instead, NF 90 membrane which produced water with acceptable TDS and has moderate permeability ended up to be more cost competitive compared to BW 30 membrane, with 17-21% lower total costs and 13-17% lower water costs. Apart from this, OPD and SEC were applied to justify the selection of optimal membrane recovery rate based on the water costs calculated. It was determined that the optimal recovery rate was 80% where the SEC and water costs were close to available water treatment plants. Overall, this study showed that the selection of membrane can be carried out by using Verbeme Cost Model assisted by assessment of membrane performance and fouling propensity, OPD and SEC. (C) 2016 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.