Complete active space self-consistent field (CASSCF), a new generalized molecular orbital approach (GMO2), and Moller-Plesset (MP) perturbation calculations are compared to determine the reliable level of perturbation theory for the oxo-transfer reaction associated with oxomolybdenum enzymes. GMO2(FCI) reproduced the CASSCF results within 0.7 kcal/mol for a small model system. Although GMO2(SDTQ) gave less reliable results (within 2 kcal/mol of the CASSCF results) than GMO2(FCI), GMO2(SDTQ) was used for larger systems because it is technically easier to perform. Comparing MP2, MP3, and MP4 to GMO2(SDTQ) revealed that MP2 and MP4 overestimated the stability of multiple M-O bonds. This overestimation is due to the low-lying orbitals in these multiply-bonded systems. Although these near-degenerate (nondynamical) correlation effects are handled better by variational methods, MP3 appears to be a reliable level of perturbation theory for these ore-transfer reactions.