By low-temperature (HNMR)-H-1 spectroscopy and thermogravimetry methods, the effect of hydrophobic (AM1) and hydrophilic (A-300) nanosilica on the process of evaporation and freezing water, linked to hygroscopic grape seed extract, biopreparation Enoxil (Ex), has been studied. It is shown that nanosilica modifies the character of binding water in composite systems. The total amount of water retained in the composite becomes substantially smaller than in pure biopreparation. This effect can be used to stabilize lyophilized biological tissues and cell cultures.