This paper proposed a novel flexible thermal control system (F-TCS) configuration for realizing thermal management for spacecrafts autonomous on-orbit service (A-OOS) demands. With a dual-ring topology which composes of a heat collecting bus, a heat dissipating bus, connection brunches and inter platform service interfaces, the F-TCS may realize not only self-reconfiguration operations but also providing heat dissipation resources for other spacecrafts or cabins. The F-TCS hydraulic and thermal dynamics were modeled, a verification testbed was also established to validate the F-TCS thermal control performance. Focused on investigating the self-reconfiguration and thermal control cooperative operations, several typical A-OOS cases were imposed on the F-TCS, numerical simulations and experimental validations were respectively implemented. Both results demonstrated that the meticulously designed F-TCS is capable of offering self-topological reconfiguration with fast time response and robust temperature control performances, high systemic heat transfer efficiency is also recommended from the point of view of energy saving. The F-TCS is suggested as a promising solution for A-OOS owing to its higher reliability and promising autonomous maintenance potential which is suitable for future spacecrafts thermal management requirements. (C) 2017 Elsevier Ltd. All rights reserved.