The energy landscape of the Middle East and North Africa (MENA) region has undergone a significant transformation in recent years as a result of intersecting technological, economic and political trends, both regional and international. The evolving dynamics of international energy markets, increased diversification of energy sources, global concerns for climate change, and regional conflict are among the leading factors impacting the evolution of MENA energy policy. This paper provides an assessment and outlook for energy policy in the MENA region within the context of the myriad factors impacting policy design and implementation. A review and analysis of the social, political and economic factors that are impacting regional energy policy is provided and followed by analysis of regional energy policy with consideration of hydrocarbon exploration and production, regional energy trade, demand management and clean energy production. The findings show that the MENA region is in the midst of an energy transition that has uncertain outcomes but will undoubtedly have long lasting impacts on the global energy system.