Venturi scrubbers provide highly efficient removal of particles from dust-laden gases. A uniform distribution of droplets improves the collection efficiency. Most computational models used to predict the dispersion of liquid in scrubbers employ the Boll correlation to calculate the mean droplet size. Given the lack of studies considering the effect of droplet size distribution on the liquid dispersion in Venturi scrubbers, the present work provides an experimental and numerical evaluation of this effect. Experimental measurements of droplet size distribution and liquid dispersion were made under different conditions. The fluid dynamic was simulated with ANSYS Fluent 14.0 software, using a discrete phase trajectory model. The simulations were performed with droplet size distributions measured experimentally and predicted using parameters from literature. The results for the simulated liquid dispersions were in agreement with the experimental data and indicated a strong dependence of the liquid distribution in the scrubber on the parameter values used in the droplet size distribution model.