Under atmospheric pressure, the solubilities of adipic acid, glutaric acid, and succinic acid in acetic acid + cyclohexanone mixtures were measured respectively by using the laser dynamic method in which the temperature ranged from 298.55 to 340.85 K and the mass fraction of cycloyhexanone in the binary solvent mixtures ranged from 0.0 to 1.0. The results showed that the solubilities of adipic acid, glutaric acid, and succinic acid in acetic acid + cyclohexanone solvent mixtures all increased with decreasing of the mass fraction of cyclohexanone in the solvent mixtures at the constant temperature, and with the gradually increasing of temperature the measured solubilities of adipic acid, glutaric acid and succinic acid in acetic acid + cyclohexanone solvent mixtures would increase at the constant proportion solvent mixtures. The lambda h equation and the nonrandom, two liquid (NRTL) activity coefficient model were used to correlate the experimental solubilities, and the average relative deviation was lesser than 2% respectively. It was found that the solubilities calculated by these models showed a good agreement with the experimental observations. In addition, the All equation with a small number of adjustable parameters is very suitable for engineers so that they could use directly. Compared with the lambda h equation, the NRTL equation has a wider range of applications due to the stronger theory.