Here we describe the synthesis of thermoplastic polyurethanes (TPUs) from polyols and amidodiol chain extenders, each of which is prepared from glucose-derived beta-methyl-delta-valerolactone (MVL). Utilizing these novel chain extenders, we prepared TPUs with ca. 42-44 wff, hard segment content, comprising 72-75 wt% MVL-derived atoms. This compares favorably with an analogous sample prepared using 1,4butanediol as the chain extender having 57 wt%. These TPUs are ductile (600-900% strain at break) and have high tensile strength (14-33 MPa stress at break). By virtue of the nature of the diamidodiol used as chain extenders, the hard segments contain a greater density of hydrogen bonding NHC(=0) functional groups relative to those prepared using traditional short chain 1,n-alkanediols. (C) 2017 Elsevier Ltd. All rights reserved.