화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.50, 29-35, June, 2017
DOI10.1016/j.jiec.2017.02.027  Export Citation
The anterior chamber of the eye as a site for pancreatic islet transplantation
Sijin Park1, 2, and Dong Yun Lee1, 2, †
  • 1Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea
  • 2BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul 04763, Republic of Korea
E-mail:
The most viable therapy for curing type 1 diabetes mellitus is pancreatic islet transplantation. However, they are unavoidable in terms of immunogenicity, which is differently affected by transplantation site. Therefore, it is necessary to determine alternate sites to permit successful islet transplantation outcomes. This paper reviews evidence that the anterior chamber of the eye (ACE) could be a good site for islet transplantation when compared to other alternate sites. In addition, this site may be a promising technical platform for noninvasive in vivo imaging of transplanted pancreatic islets.
Keywords:Pancreatic islet;Transplantation;Immune privileged site;Anterior chamber;Eye
  1. Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B ,Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA,, Diabetes Care, 35, 1436 (2012)
  2. Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, Felldin M, Kallen R, Salmela K, Tibe A, Tufveson G, Ekdahl N, Elgue G, Korsgren O, Nilsson B, Diabetes, 54, 1755 (2005)
  3. Cabric S, Sanchez J, Lundgren T, Foss A, Felldin M, Kallen R, Salmela K, Tibell A, Tufveson G, Larsson R, Korsgren O, Nilsson B, DiabeteS, 56, 2008 (2007)
  4. Merani S, Shapiro AM, Clin. Sci., 110, 611 (2006)
  5. Andersson A, Carlsson PO, Carlsson C, Olsson R, Nordin A, Johansson M, Palm F, Tyrberg B, Kallskog O, Tillmar L, Welsh N, Mattsson G, Jansson L, Cell Biochem. Biophys. (2004) 55.
  6. Yin D, Ding JW, Shen J, Ma L, Hara M, Chong AS, Am. J. Transplant., 6, 60 (2006)
  7. Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M,, World J. Gastrointest. Pathophysiol., 3, 19 (2012)
  8. Stagner JI, Rilo HL, White KK, JOP, 8, 628 (2007)
  9. Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J, Hunter DW, Sutherland DER, J. Am. Med. Assoc., 293, 830 (2005)
  10. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV, N. Engl. J. Med., 343, 230 (2000)
  11. Gerling IC, Serreze DV, Christianson SW, Leiter EH, Diabetes, 41, 1672 (1992)
  12. Posselt AM, Naji A, Roark JH, Markmann JF, Barker CF, Ann. Surg., 214, 363 (1991)
  13. Rayat GR, Korbutt GS, Elliott JF, Rajotte RV, Cell Transplant., 6, 597 (1997)
  14. Levy MM, Ketchum RJ, Tomaszewski JE, Naji A, Barker CF, Brayman KL, Transplantation, 73, 842 (2002)
  15. Tze WJ, Tai J, Diabetes, 32, 1185 (1983)
  16. Lee HC,. Ahn KJ, Lim SK, Kim JR, Ahn YS, Lee KE, Huh KB, Transplantation, 53, 513 (1992)
  17. Bloch K, Vanichkin A, Vardi P, Transplantation, 95, E54 (2013)
  18. Nasr IW, Wang YN, Gao G, Deng SY, Diggs L, Rothstein DM, Tellides G, Lakkis FG, Dai ZH, J. Immunol. Methods, 174, 6161 (2005)
  19. Refaie A, Gabr M, Mahmoud I, Bakr MA, El-Baz M, Ghoneim MA, Transplant. Proc., 30, 400 (1998)
  20. Mahmoud IM, Gabr MM, Refaie AF, El-Baz MA, Bakr MA, Ghoneim MA, Transplant. Proc., 30, 369 (1998)
  21. Ilegems E, Dicker A, Speier S, Sharma A, Bahow A, Edlund PK, Leibiger IB, Berggren PO, Proc. Natl. Acad. Sci. U. S. A., 110, 20581 (2013)
  22. Speier S, Nyqvist D, Cabrera O, Yu J, Molano RD, Pileggi A, Moede T, Kohler M, Wilbertz J, Leibiger B, Ricordi D, Leibiger IB, Caicedo A, Berggren PO, Nat. Med., 14, 574 (2008)
  23. Mojibian M, Harder B, Hurlburt A, Bruin JE, Asadi A, Kieffer TJ, Diabetologia, 56, 2213 (2013)
  24. Perez VL, Caicedo A, Berman DM, Arrieta E, Abdulreda MH, Rodriguez-Diaz R, Pileggi A, Hernandez E, Dubovy SR, Parel JM, Ricordi C, Kenyon NM, Kenyon NS, Berggre PO, Diabetologia, 54, 1121 (2011)
  25. De Vos P, De Haan BJ, Vegter D, Hillebrands JL, Strubbe JH, Bruggink JE, Van Schilfgaarde R, Horm. Metab. Res., 30, 721 (1998)
  26. Merani S, Toso C, Emamaullee J, Shapiro AMJ, Br. J. Surg., 95, 1449 (2008)
  27. Bennet W, Groth CG, Larsson R, Nilsson B, Korsgren O, Ups. J. Med. Sci., 105, 125 (2000)
  28. Moberg L, Olsson A, Berne C, Felldin M, Foss A, Kallen R, Salmela K, Tibell A, Tufveson G, Nilsson B, Korsgren O, Transplantation, 76, 1285 (2003)
  29. Ozmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B, Diabetes, 51, 1779 (2002)
  30. Ricordi C, Tzakis AG, Carroll PB, Zeng TJ, Rilo HL, Alejandro R, Shapiro A, Fung JJ, Demetris AJ, Mintz DH, et al., Transplantation, 53, 407 (1992)
  31. Tzakis AG, Ricordi C, Alejandro R, Zeng Y, Fung JJ, Todo S, Demetris AJ, Mintz DH, Starzl TE, Lancet, 336, 402 (1990)
  32. Ricordi C, Diabetes, 52, 1595 (2003)
  33. Linetsky E, Bottino R, Lehmann R, Alejandro R, Inverardi L, Ricordi C, Diabetes, 46, 1120 (1997)
  34. First MR, Am. J. Kidney Dis., 29, 303 (1997)
  35. Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J, Science, 252, 839 (1991)
  36. Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL, Science, 250, 556 (1990)
  37. Daloze P, Chen H, Luo H, Xu D, Shan S, Wu J, Transplant. Proc., 25, 721 (1993)
  38. Malinowski M, Pratschke J, Lock J, Neuhaus P, Stockmann M, Ann. Transplant., 15, 60 (2010)
  39. Filler G, Neuschulz I, Vollmer I, Amendt P, Hocher B, Nephrol. Dial. Transplant., 15, 867 (2000)
  40. Ryan EA, Lakey JR, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV, Shapiro AM, Diabetes, 51, 2148 (2002)
  41. Noguchi H, Matsumoto S, Matsushita M, Kobayashi N, Tanaka K, Matsui H, Tanaka N, Acta Med. Okayama, 60, 71 (2006)
  42. Medawar PB, Br. J. Exp. Pathol., 29, 58 (1948)
  43. Ferguson J, Scothorne RJ, J. Anat., 124, 1 (1977)
  44. Selawry HP, Cameron DF, Cell Transplant, 2, 123 (1993)
  45. Tze WJ, J. Tai, Transplantation, 38, 107 (1984)
  46. Watt PC, Mullen Y, Nomura Y, Watanabe Y, Brunicardi FC, Anderson C, Zinner MJ, Passaro EP, J. Surg. Res., 56, 367 (1994)
  47. Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A, Science, 249, 1293 (1990)
  48. Tze WJ, J. Tai, Transplantation, 47, 1053 (1989)
  49. Tze WJ, J. Tai, Metabolism, 33, 785 (1984)
  50. Lazard D, Vardi P, Bloch K, Diabetes Metab. Res. Rev., 32, 11 (2016)
  51. Mielke JG, Wangi YT, in: S. Rahman (Ed.), Insulin, Synaptic Function, and Opportunities for Neuroprotection, 2011, pp. 133.
  52. Yarchoan M, Arnold SE, Diabetes, 63, 2253 (2014)
  53. Craft S, Curr. Alzheimer Res., 4, 147 (2007)
  54. Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D, Neurology, 50, 164 (1998)
  55. Frolich L, Blum-Degen D, Bernstein HG, Engelsberger S, Humrich J, Laufer S, Muschner D, Thalheimer A, Turk A, Hoyer S, Zochling R, Boissl KW, Jellinger K, Riederer P, J. Neural. Transm., 150, 423 (1998)
  56. Kern W, Peters A, Fruehwald-Schultes B, Deininger E, Born J, Fehm HL, Neuroendocrinology, 74, 270 (2001)
  57. Franca LR, Auharek SA, Hess RA, Dufour JM, Hinton BT, Adv. Exp. Med. Biol., 763, 237 (2012)
  58. Kaur G, Thompson LA, Dufour JM, Semin. Cell Dev. Biol., 30, 36 (2014)
  59. Kin T, Rajotte RV, Dufour JM, Korbutt GS, Cell Transplant., 11, 547 (2002)
  60. Valdes-Gonzalez RA, Dorantes LM, Garibay GN, Bracho-Blanchet E, Mendez AJ, Davila-Perez R, Elliott RB, Teran L, White DJ, Eur. J. Endocrinol., 153, 419 (2005)
  61. Streilein JW, Nat. Rev. Immunol., 3, 879 (2003)
  62. Streilein JW, Niederkorn JY, J. Exp. Med., 153, 1058 (1981)
  63. Korsgren O, Jansson L, Andersson A, Sundler F, Transplantation, 56, 138 (1993)
  64. Brissova M, Powers AC, Diabetes, 57, 2269 (2008)
  65. Speier S, Nyqvist D, Koehler M, Caicedo A, Leibiger IB, Berggren PO, Nat. Protoc., 3, 1278 (2008)
  66. Abdulreda MH, Caicedo A, Berggren PO, Jove-J. Vis. Exp. (73) (2013).
  67. Abdulreda MH, Faleo G, Molano RD, Lopez-Cabezas M, Milina J, Tan Y, Echeverria OA, Zahr-Akrawi E, Rodriguez-Diaz R, Edlund PK, Leibiger I, Bayer AL, Perez V, Ricordi C, Caicedo A, Pileggi A, Erggren PO, Proc. Natl. Acad. Sci U.S.A., 108, 12863 (2011)
  68. Ilegems E, van Krieken PP, Edlund PK, Dicker A, Alanentalo T, Eriksson E, Mandic S, Ahlgren U, Berggren PO, Sci. Rep. 5 (2015).
  69. Adeghate E, Ponery AS, Ahmed I, Donath T, Eur. J. Morphol., 39, 257 (2001)
  70. Adeghate E, Donath T, Pancreas, 5, 298 (1990)
  71. Bickfordwimer P, Granholm AC, Bygdeman M, Hoffer B, Olson L, Seiger A, Stromberg I, Proc. Natl. Acad. Sci. U. S. A., 84, 5957 (1987)