Preparation of cationic functional polymer poly(Acryloxyethyltrimethyl ammonium chloride)/SiO2 and its adsorption characteristics for heparin

Jiying Men; Jianfeng Guo; Weihong Zhou; Nanyan Dong; Xilun Pang; Baojiao Gao

Korean Journal of Chemical Engineering, Vol.34, No.7, 1889-1895, July, 2017

DOI10.1007/s11814-017-0131-0 Export Citation

Preparation of cationic functional polymer poly(Acryloxyethyltrimethyl ammonium chloride)/SiO2 and its adsorption characteristics for heparin

Jiying Men^†, Jianfeng Guo, Weihong Zhou, Nanyan Dong, Xilun Pang, and Baojiao Gao

Department of Chemical Engineering, North University of China, Taiyuan 030051, P. R. China

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Ion-exchange is a widely used purification technology in the heparin manufacturing process. To improve the rate and efficiency, the cationic monomer Acryloxyethyltrimethyl ammonium chloride (DAC) was grafted on silica gel particles by using a surface-initiated graft-polymerization technique, and a novel adsorption polymer of PDAC/SiO2 was prepared. The adsorption experiments of PDAC/SiO2 for heparin show that there are strong electrostatic interactions between heparin with a high density of negative charges and PDAC/SiO2 that exists in many quaternary ammonium cations. Comparing the adsorption kinetics of PDAC/SiO2 with D201 anionic strong alkali exchange resin, PDAC/SiO2 shows higher adsorption capacity and faster adsorption rate. The pH and temperature of solutions have a great influence on the adsorption amount, and there is a maximum adsorption capacity of 121mg/g when pH=7 at 25 °C. The adsorption of PDAC/SiO2 for heparin is an exothermic process and driven by entropy.

Keywords:Heparin;Cationic Monomer;Electrostatic Interaction;DAC;Adsorption

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[16] Ngo VG, Bressy C, Leroux C, Margaillan A, Polymer, 50(14), 3095 (2009)

[17] Yang B, Solakyildirim K, Chang Y, Linhardt RJ, Anal. Bioanal. Chem., 399, 541 (2011)

[18] Flengsrud R, Larsen ML, Odegaard OR, Thromb. Res., 129, e409 (2010)

[19] Gunay NS, Robert JL, J. Chromatogr. A, 1014, 225 (2003)

[20] Gao BJ, Gao YC, Li YB, Chem. Eng. J., 158(3), 542 (2010)

[21] Cestari AR, Vieira EFS, Mattos CRS, J. Chem. Thermodyn., 38(9), 1092 (2006)

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[24] Zhang YY, Gao BJ, Xu ZQ, J. Phys. Chem. B, 117(18), 5730 (2013)