An electrochemical nanofilm sensor for determination of 1-hydroxypyrene using molecularly imprinted receptors

Do-Hyeon Yang; Chang-Soo Lee; Beung-Hoon Jeon; Sung Mook Choi; Yong-Dae Kim; Jae Sup Shin; Heon Kim

Journal of Industrial and Engineering Chemistry, Vol.51, 106-112, July, 2017

DOI10.1016/j.jiec.2017.02.020 Export Citation

An electrochemical nanofilm sensor for determination of 1-hydroxypyrene using molecularly imprinted receptors

Do-Hyeon Yang^{1, 2}, Chang-Soo Lee³, Beung-Hoon Jeon², Sung Mook Choi⁴, Yong-Dae Kim^{5, †}, Jae Sup Shin^{2, †}, and Heon Kim⁵

¹aR&D Lab., PNS Technology, Inc., 301 Yeonsung University, 34, Yanghwa-ro 37 beon-gil, Manan-gu, Anyang-si, Gyeonggi-do 439-730, South Korea
²Department of Chemistry, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 28644, South Korea
³Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), 125 Gwahak-ro Yuseong-gu, Daejeon 34141, South Korea
⁴R&D Lab., PNS Technology, Inc., 301 Yeonsung University, 34, Yanghwa-ro 37 beon-gil, Manan-gu, Anyang-si, Gyeonggi-do 439-730, South Korea
⁵Department of Preventive Medicine, College of Medicine, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 28644, South Korea

E-mail:,

A novel electrochemical nanofilm sensor for 1-hydroxypyrene (1-OHP) was developed based on a molecular imprinted TiO2 gel matrix, which was prepared with Ti(O-n-Bu)4 and 1-OHP using sol.gel technology. Cyclic voltammetry (CV) showed that guest binding on the non-imprinted sensor resulted in nearly the same current changes for all guest molecules, indicating non-specific binding onto the TiO2 gel matrix. In contrast, binding at the molecular imprinted sensor revealed that the selectivity for 1-OHP relative to structurally related guest molecules was estimated to be 1.8-6.7 times greater at 1 x10-9 M, reflecting its specific adsorption and binding capacity for the template molecule.

Keywords:Molecular imprinting;TiO2 gel matrix;Electrochemical sensor;1-Hydroxypyrene;Polycyclic aromatic hydrocarbon

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Lee SW, Yang DH, Kunitake T, Sens. Actuators B-Chem., 104, 35 (2005)
Yang DH, Ju MJ, Maeda A, Lee SW, Sens. Mater., 20, 191 (2008)
Ju M J, Yang DH, Takahara N, Hayashi K, Toko K, Lee SW, Kunitake T, Chem. Commun., 44, 2630 (2007)
Ju MJ, Yang DH, Lee SW, Kunitake T, Hayashi K, Toko K, Sens. Actuators B-Chem., 123, 359 (2007)
Lahav M, Kharitonov AB, Katz O, Kunitake T, Willner I, Anal. Chem., 73, 720 (2001)
Yang DH, Ham YR, Oh MH, Yoon YS, Shin JS, Kim YD, Kim H, Curr. Appl. Phys., 9(2), e136 (2009)
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[1] Hemminki K, Veidebaum T, J. Scand, Work Environ. Health, 25, 33 (1999)

[2] Lijinsky W, Mutat. Res., 259, 251 (1991)

[3] Jongeneelen FJ, Anzion RB, Henderson PT, J. Chromatogr., 413, 227 (1987)

[4] Schere G, Frank S, Riedel K, Meger-Kossien I, Renner T, Biomark. Prev., 9, 373 (2000)

[5] Kim H, Cho SH, Kang JW, Kim YD, Nan HM, Lee CH, Kawamoto T, Int. Arch. Occup. Environ. Health, 74, 59 (2000)

[6] Kishikawaa N, Wadaa M, Kurodaa N, Akiyamab S, Nakashimac K, J. Chromatogr. B, 789, 257 (2003)

[7] Martinez-Salinas RI, Leal ME, Batres-Esquivel LE, Dominguez-Cortinas G, Calderon N, Diaz-Barriga F, Perez-Maldonado IN, Int. Arch. Occup. Environ. Health, 83, 617 (2010)

[8] Chen HW, Anal. Sci. Technol., 23, 1221 (2007)

[9] Cahours X, Blancher M, Rey M, J. Sep. Sci., 32, 3403 (2009)

[10] Fan RF, Dong TL, Zang WB, Wang Y, Yu ZQ, Shen GY, Fu JM, J. Chromatogr. B, 836, 92 (2006)

[11] Beach DG, Quilliam MA, Hellou J, J. Chromatogr. B, 877, 2142 (2009)

[12] Campo L, Rossella F, Fustinoni S, J. Chromatogr. B, 875, 531 (2008)

[13] Shin HS, Lim HH, J. Chromatogr. B, 879, 489 (2011)

[14] Wulff G, Chem. Rev., 102(1), 1 (2002)

[15] Shin MJ, Shin YJ, Shin JS, J. Ind. Eng. Chem., 20(1), 91 (2014)

[16] Yang DH, Takahara N, Lee SW, Kunitake T, Sens. Actuators B-Chem., 130, 379 (2008)

[17] Yang DH, Ju MJ, Maeda K, Hayashi K, Toko K, Lee SW, Kunitake T, Biosens. Bioelectron., 22, 388 (2006)

[18] Yu P, Sun Q, Li J, Tan Z, Yan Y, Li C, J. Ind. Eng. Chem., 29, 349 (2015)

[19] Meng M, Feng Y, Guan W, Liu Y, Xi Y, Yan Y, J. Ind. Eng. Chem., 20(6), 3975 (2014)

[20] Dickert FL, Besenbock H, Tortschanoff M, Adv. Mater., 10(2), 149 (1998)

[21] Dickert FL, Hayden O, Halikias KP, Analyst, 126, 766 (2001)

[22] Kirsch N, Hart JP, Bird DJ, Luxton RW, McCalley DV, Analyst, 126, 1936 (2001)

[23] Kirsch N, Honeychurch KC, Hart JP, Whitcombeb MJ, Electroanalysis, 17, 571 (2005)

[24] Krupadam RJ, Nesterov EE, Spivak DA, J. Hazard. Mater., 274, 1 (2014)

[25] Krupadam RJ, Khan MS, Wate SR, Water Res., 44, 681 (2010)

[26] Lai JP, Niessner R, Knopp D, Anal. Chim. Acta, 522, 137 (2004)

[27] Wang YQ, Yang YY, Xu L, Zhang J, Electrochim. Acta, 56(5), 2105 (2011)

[28] Katz A, Davis ME, Nature, 403, 286 (2000)

[29] Fireman-Shoresh S, Avnir D, Marx S, Chem. Mater., 15, 3607 (2003)

[30] Mixutani N, Yang DH, Selyanchyn R, Korposh S, Lee SW, Kunitake T, Anal. Chim. Acta, 694, 142 (2011)

[31] Lahav M, Kharitonov AB, Willner I, Chem. Eur. J., 7, 3992 (2001)

[32] Yang DH, Lee SW, Kunitake T, Chem. Lett., 34(12), 1686 (2005)

[33] Araki K, Yang DH, Wang T, Selyanchyn R, Lee SW, Kunitake T, Anal. Chim. Acta, 779, 72 (2013)

[34] Lee SW, Yang DH, Kunitake T, Sens. Actuators B-Chem., 104, 35 (2005)

[35] Yang DH, Ju MJ, Maeda A, Lee SW, Sens. Mater., 20, 191 (2008)

[36] Ju M J, Yang DH, Takahara N, Hayashi K, Toko K, Lee SW, Kunitake T, Chem. Commun., 44, 2630 (2007)

[37] Ju MJ, Yang DH, Lee SW, Kunitake T, Hayashi K, Toko K, Sens. Actuators B-Chem., 123, 359 (2007)

[38] Lahav M, Kharitonov AB, Katz O, Kunitake T, Willner I, Anal. Chem., 73, 720 (2001)

[39] Yang DH, Ham YR, Oh MH, Yoon YS, Shin JS, Kim YD, Kim H, Curr. Appl. Phys., 9(2), e136 (2009)

[40] Yang DH, Shin MJ, Kim M, Kim YD, Kim H, Shin JS, Microchim. Acta, 183, 1601 (2016)

[41] Shin YJ, Kim SH, Yang DH, Kwon H, Shin JS, J. Ind. Eng. Chem., 16(3), 380 (2010)