Chitosan-Based Composite Hydrogels for Biomedical Applications

Tepeng Wu; Yi Li; Doo Sung Lee

Macromolecular Research, Vol.25, No.6, 480-488, June, 2017

DOI10.1007/s13233-017-5066-0 Export Citation

Chitosan-Based Composite Hydrogels for Biomedical Applications

Tepeng Wu, Yi Li, and Doo Sung Lee^†

Theranostic Macromolecules Research Center and School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi 16419, Korea

E-mail:

During the last decade, hydrogels prepared from biodegradable polymers, especially natural biodegradable polymers, have been studied extensively for drug delivery and tissue engineering. Chitosan, one of the most abundant natural polymers, is a good candidate and the most widely studied polymer for biomedical applications. To improve physiochemical, biological and other properties of chitosan, many efforts have been made in fabrication of chitosan-based composited hydrogels by physical blending or chemical modifications. Frequently used components include natural polymers, synthetic polymers, inorganic particles and small molecules. In this review, we summarize recent works that are related to chitosanbased composite hydrogels for biomedical applications.

Keywords:chitosan;composite hydrogels;drug delivery;tissue engineering

[References]

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[Referenced By]

[1] Rinaudo, Prog. Polym. Sci, 31, 603 (2006)

[2] George M, Abraham TE, J. Control. Release, 114, 1 (2006)

[3] Baldrick P, Regul. Toxicol. Pharmacol., 56, 290 (2010)

[4] Sogias IA, Williams AC, Khutoryanskiy VV, Biomacromolecules, 9(7), 1837 (2008)

[5] Yao KD, Yao AL, Yin YJ, Chitosan-Based Hydrogels: Functions and Application, CRC Press, London, 2010.

[6] Ivanova EP, Bazaka K, Crawford RJ, New Functional Biomaterials for Medicine and Healthcare, 1st ed., Woodhead Publishing Limited, Cambridge, 2014.

[7] Xu Y, Zhan C, Fan L, Wang L, Zheng H, Int. J. Pharm., 336, 329 (2007)

[8] Lin YH, Liang HF, Chung CK, Chen MC, Sung HW, Biomaterials, 26, 2105 (2005)

[9] Sarmento B, Ribeiro A, Veiga F, Sampaio P, Neufeld R, Ferreira D, Pharm. Res., 24, 2198 (2007)

[10] Baysal K, Aroguz AZ, Adiguzel Z, Baysal BM, Int. J. Biol. Macromol., 59, 342 (2013)

[11] Dai YN, Li P, Zhang JP, Wang AQ, Wei Q, J. Biomed. Mater. Res., 86, 493 (2008)

[12] Long Z, Mitomo H, Yosh F, J. Bioact. Compat. Polym., 23, 319 (2008)

[13] Tang Y, Wang X, Li Y, Lei M, Du Y, Kennedy JF, Knill CJ, Carbohydr. Polym., 82, 833 (2010)

[14] Wang L, Stegemann JP, Biomaterials, 31, 3976 (2010)

[15] Chicatun F, Pedraza CE, Ghezzi CE, Marelli B, Kaartinen MT, McKee MD, Nazhat SN, Biomacromolecules, 12(8), 2946 (2011)

[16] Wu X, Black L, Santacana-Laffitte G, Patrick CW, J. Biomed. Mater. Res., 81, 59 (2007)

[17] Rafat M, Li F, Fagerholm P, Lagali NS, Watsky MA, Munger R, Matsuura T, Griffith M, Biomaterials, 29, 3960 (2008)

[18] Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV, Biomaterials, 26, 7616 (2005)

[19] Huang X, Zhang Y, Zhang X, Xu L, Chen X, Wei S, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 33, 4816 (2013)

[20] Peng Z, Peng Z, Shen Y, Polym. -Plast. Technol. Eng., 50, 1160 (2011)

[21] Tan H, Chu CR, Payne KA, Marra KG, Biomaterials, 30, 2499 (2009)

[22] Sun JC, Xiao C, Tan HP, Hu XH, J. Appl. Polym. Sci., 129(2), 682 (2013)

[23] Park H, Choi B, Hu J, Lee M, Acta Biomater., 9, 4779 (2013)

[24] Jiang Y, Meng X, Wu Z, Qi X, Carbohydr. Polym., 144, 245 (2016)

[25] Zu Y, Zhang Y, Zhao X, Shan C, Zu S, Wang K, Li Y, Ge Y, Int. J. Biol. Macromol., 50, 82 (2012)

[26] Costa-Junior ES, Barbosa-Stancioli EF, Mansur AAP, Vasconcelos WL, Mansur HS, Carbohydr. Polym., 76, 472 (2009)

[27] Mansur HS, Costa EDS, Mansur AAP, Barbosa- Stancioli EF, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 1574 (2009)

[28] Tang YF, Du YM, Hu XW, Shi XW, Kennedy JF, Carbohydr. Polym., 67, 491 (2007)

[29] Garnica-Palafox IM, Sanchez-Arevalo FM, Velasquillo C, Garcia-Carvajal ZY, Garcia-Lopez J, Ortega-Sanchez C, Ibarra C, Luna-Barcenas G, Solis-Arrieta L, J. Biomater. Sci.-Polym. Ed., 25, 32 (2014)

[30] Tang Y, Du Y, Li Y, Wang X, Hu X, J. Biomed. Mater. Res., 91, 953 (2009)

[31] Yang SH, Lin FH, Yang JM, Chen KS, J. Biomed. Mater. Res., 83, 304 (2007)

[32] Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M, J. Control. Release, 103, 609 (2005)

[33] Wu J, Wei W, Wang LY, Su ZG, Ma GH, Biomaterials, 28, 2220 (2007)

[34] Zhong C, Wu J, Reinhart-King CA, Chu CC, Acta Biomater., 6, 3908 (2010)

[35] Ma G, Yang D, Li Q, Wang K, Chen B, Kennedy JF, Carbohydr. Polym., 79, 620 (2010)

[36] Zhang YL, Tao L, Li SX, Wei Y, Biomacromolecules, 12(8), 2894 (2011)

[37] Jung S, Yi H, Langmuir, 28(49), 17061 (2012)

[38] Ding CX, Zhao LL, Liu FY, Cheng J, Gu JX, Shan-Dan, Liu CY, Qu XZ, Yang ZZ, Biomacromolecules, 11(4), 1043 (2010)

[39] Park KM, Lee SY, Joung YK, Na JS, Lee MC, Park KD, Acta Biomater, 5, 1956 (2009)

[40] Choi JS, Yoo HS, J. Biomed. Mater. Res., 95, 564 (2010)

[41] Kim JY, Choi WI, Kim YH, Tae G, Biomaterials, 34, 1170 (2013)

[42] Das RK, Kasoju N, Bora U, Nanomedicine, 6, 153 (2010)

[43] Zhou Y, Yang D, Ma G, Tan H, Jin Y, Nie J, Polym. Adv. Technol., 19, 1133 (2008)

[44] Chen SL, Liu MZ, Jin SP, Chen Y, J. Appl. Polym. Sci., 98(4), 1720 (2005)

[45] Han J, Wang K, Yang D, Nie J, Int. J. Biol. Macromol., 44, 229 (2009)

[46] Wei D, Sun W, Qian W, Ye Y, Ma X, Carbohydr. Res., 344, 2375 (2009)

[47] Sanpui P, Murugadoss A, Prasad PV, Ghosh SS, Chattopadhyay A, Int. J. Food Microbiol., 124, 142 (2008)

[48] Wang C, Huang Y, New J. Chem., 38, 657 (2014)

[49] Chen R, Chen Q, Huo D, Ding Y, Hu Y, Jiang X, Colloids Surf. B: Biointerfaces, 97, 132 (2012)

[50] Baei P, Jalili-Firoozinezhad S, Rajabi-Zeleti S, Tafazzoli-Shadpour M, Baharvand H, Aghdami N, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 63, 131 (2016)

[51] Hua S, Yang H, Wang W, Wang A, Appl. Clay Sci., 50, 112 (2010)

[52] Liu KH, Liu TY, Chen SY, Liu DM, Acta Biomater., 4, 1038 (2008)

[53] Liu M, Wu C, Jiao Y, Xiong S, Zhou C, J. Mater. Chem., 1, 2078 (2013)

[54] Niranjan R, Koushik C, Saravanan S, Moorthi A, Vairamani M, Selvamurugan N, Int. J. Biol. Macromol., 54, 24 (2013)

[55] Wu J, Su ZG, Ma GH, Int. J. Pharm., 315, 1 (2006)

[56] Crompton KE, Goud JD, Bellamkonda RV, Gengenbach TR, Finkelstein DI, Horne MK, Forsythe JS, Biomaterials, 28, 441 (2007)