Aluminum monoliths were used as substrates to prepare structured catalysts. A rough alumina layer was generated on the surface of the substrates by anodizing followed by hydrothermal treatments. The dip-coating technique was used for coating the monolithic substrates. Aqueous suspensions with 0.15 and 0.30g/g of Ni-Nb mixed oxides catalysts were prepared for that purpose. Colloidal SiO2 was added as a binder in order to obtain homogeneous and adherent coatings. The samples were characterized by SEM, TPR, XPS, XRD, and N-2 adsorption and tested in the oxidative dehydrogenation (ODH) of ethane to ethylene. The silica particles produced a drop in catalytic activity without affecting ethylene selectivity. The former effect was attributed mainly to a decrease in surface nickel concentration and an increase in reduction temperature. The presence of anodized aluminum substrates in the reaction environment did not have a significant influence on catalytic activity and product distribution, as observed for the coated monoliths used in this work, thus being a useful material to prepare structured catalysts for low-temperature ethane ODH.