Novel visible-light-driven Bi24O31Cl10 nanosheets were firstly prepared via a facile solvothermal method followed a thermal treatment. The physicochemical properties of as-synthesized sample was characterized by X-ray diffraction, X-rays photoelectron spectroscopy, scanning electronic microscopy, transmission electron microscopy, and UV-Vis spectroscopy. The photocatalytic activity of the photocatalyst was evaluated by degradation of tetracycline hydrochloride (TC-HCl) under visible-light irradiation. Results shown that the Bi24O31Cl10 nanosheets exhibited dramatically enhanced photocatalytic activity towards TC-HCl degradation in comparison with the traditional BiOCl and TiO2 (P25). The nanosheets also displayed excellent photochemical stability for efficient removal of TC-HCl. This work provides a simple approach to fabricate the novel Bi-based nanomaterial and will bring about potential application in treatment of antibiotic pollutant. [GRAPHICS] .