We reported a novel class of organic-inorganic hybrid material based on the ionic liquid bis(1(3-trimethoxysilylpropyl)-3-methyl-imidazolium) nickel tetrachloride tethered to colloidal silica nanoparticles and characterized by H-1 NMR spectroscopy, scanning electron microscope, energy dispersive spectroscopy, thermogravimetric analysis, and dynamic light scattering. Meanwhile, we compared the catalytic activity of ionic liquid immobilized colloidal nano-silica with ionic liquid immobilized nano-SiO2 produced by sol-gel route. A proper, atom-economical, straightforward one-pot multicomponent synthetic route for the synthesis of propargylamines in good yields has been devised using ionic liquid tethered to colloidal silica nanoparticles.