Cu-based bifunctional materials were examined for carbon dioxide conversion, thus producing the syngas from hydrogen, which can be attained using surplus electrical energy. Catalysts were synthesized by deposition-precipitation fabrication method, i.e., copper on Al2O3, CeO2, SiO2, TiO2, and ZrO2. To investigate chemical reaction kinetics, the turnover was screened in a parallel high-throughput packed-bed reactor system. The results indicated that catalytic pathway mechanisms were affected by the substrate. An optimal supporting oxide may thus contribute to the engineering and intensification of unconventional feedstock processing, e.g., CO2, as well as the design of emerging catalysis routes. The produced synthesis gas may be readily used for basic chemical platforms, such as methanol.