The mechanism and optimization of the dry pressure drop within a novel structured packing, Winpak, was investigated by computational fluid dynamic simulations. The contribution of the dry pressure drop was decomposed into two components. The drag term was obtained according to an existing model. The frictional pressure drop was simulated in a new representative elementary unit. Several structures of Winpak were designed to study the effect of the packing dimensions. Results indicate the windows on the packing sheets have significant effect. Accordingly, the cutting angle of windows was optimized to reduce dry pressure drop. A set of correlations for predicting the dry pressure drop was established ultimately and validated by experimental data.